Ku86 exists as both a full-length and a protease-sensitive natural variant in multiple myeloma cells
نویسندگان
چکیده
منابع مشابه
Case report: Full mouth rehabilitation of a patient with multiple myeloma and worn dentition
Abstract Treatment planning for a patient with worn dentition and systemic disorder needs to assess different aspects of patient’s oral condition and life. This study presents prosthetic reconstruction approach of a patient with worn dentition using metal ceramic restorations, and removable partial denture. It showed that a simple and low cost but careful treatment planning may results in im...
متن کاملKu86 variant expression and function in multiple myeloma cells is associated with increased sensitivity to DNA damage.
Ku is a heterodimer of Ku70 and Ku86 that binds to double-stranded DNA breaks (DSBs), activates the catalytic subunit (DNA-PKcs) when DNA is bound, and is essential in DSB repair and V(D)J recombination. Given that abnormalities in Ig gene rearrangement and DNA damage repair are hallmarks of multiple myeloma (MM) cells, we have characterized Ku expression and function in human MM cells. Tumor c...
متن کاملMultiple Myeloma Presenting as Respiratory Stridor
Extramedullary plasmacytoma occurs in 18% of patients with multiple myeloma. Laryngeal involvement in multiple myeloma is rare, and only a few cases have been reported. We present a case of a 44-year-old women with multiple myeloma who presented with stridor due to a mass involving the larynx which was initially proven to be plasmacytoma on biopsy. She had evidence of multiple myeloma of IgA la...
متن کاملIs 99m Tc-methylene diphosphonate bone scintigraphy a sensitive method for detecting bone lesions in multiple myeloma?
Background: Bone lesion in multiple myeloma (MM) is most commonly presented as a lytic lesion in this disease. Determination of extent of bone lesions in MM is necessary to follow-up the patients. Whole body bone scan with 99m, Tc-methylene diphosphonate (MDP) has a lower sensitivity than other modalities. Methods: From the patients with MM admitted to Ayatollah Rouhani Hospital of Babol-Iran ...
متن کاملNon-secretory myeloma: a rare variant of multiple myeloma.
The spectrum of plasma cell neoplasm represents indolent conditions like Monoclonal Gammopathy of Undetermined Significance (MGUS) to more aggressive multiple myeloma and plasma cell leukemia. Non-secretory myeloma comprises less than 01% of this spectrum where serum protein electrophoresis and quantitative immunoglobulins remain essentially normal. We are presenting a case report of this rare ...
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ژورنال
عنوان ژورنال: Cancer Cell International
سال: 2008
ISSN: 1475-2867
DOI: 10.1186/1475-2867-8-4